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21.1.5.4 Method 4: Beckmann Rearrangement from Oximes

DOI: 10.1055/sos-SD-021-00115

Judd, W. R.; Katz, C. E.; Aubé, J.Science of Synthesis, (200521156.

The Beckmann rearrangement, which involves the conversion of oximes into amides or lactams in the presence of an acid or acylating agent, was discovered in 1886 and is thus one of the oldest reactions in organic synthesis (Scheme 29).[‌61‌,‌62‌] It remains a widely used method for the introduction of nitrogen into organic molecules.

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