Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content.
21.1.5.8.1 Variation 1: The Kindler Modification

DOI: 10.1055/sos-SD-021-00115

Judd, W. R.; Katz, C. E.; Aubé, J.Science of Synthesis, (200521175.

The Kindler modification of the Willgerodt reaction involves heating the ketone, e.g. 121, with approximately equimolar amounts of sulfur and dry amines, such as ammonia and primary or secondary amines, instead of with aqueous ammonium polysulfide (i.e., the reaction occurs under anhydrous conditions). A thioamide, e.g. 122, is formed in this variation, which has become known as the WillgerodtKindler reaction (Scheme 56).

Meeeee 88 Mee MeeeeeeeeeMeeeeee Meeeeeee[‌888‌,‌888‌]

Me eee Meeeeee eeeeeeeeeeee, eee eee ee eeee-eeeeeee eeeeee eeeeeeeeee eee eeee eee eee eeee eeeeeeeee eeee eee eeeeeeeeee eeeeeeee ee eee Meeeeeeeee eeeeeeee, eeeeeeee eee eeeeeeee eeeee eeee eeeeee eeeeeeeeee. Meeeeeee eeeeeeeeee ee eeee eeeeeeeeee eeee, eeee eeeee eeeeeee eee eeeeeeeee eeeeee, eeee ee eeeeeee, eeeeeeeeeee, eee eeeeeeeeeeeee, eee ee eeee. Mee Meeeeee eeeeeee eee eeeeeee eeeeeeeee eee eeeeeeeee eeeee ee eee Meeeeeeeee eeeeeeee, eee ee eee eeee eeeeeeee ee eeeeeeeee eee eeeeee eeeee eeeee eeeeeeeee.[‌888‌]

Meeeeeeeeeee Meeeeeeee

8-(8-Meeeeeee-8-eeeeeeeeeeeeee)eeeeeeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

M eeeeeee ee eeeeee 888 (88.8e, 888eeee), M8, (88.8e, 888eeee), eee eeeeeeeeee (888eM) eee eeeeeeee eee 88e. M eeeee eeeeee ee eeeeeeeeee eee eeee ee eeeeeee eeeeeeeeeeeeee eeeeee eeeeee. Mee eee eeeeeee eee eeeeee eeee MeMM (888eM), eeeeee, eee eeeeeeee ee eeee e eeeee, eeeee eee eeeeee eeee eeee MeMM eee eeeee; eeeee: 888e (88%); ee 888888°M (MeMM).

References