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DOI:
10.1055/sos-SD-021-00515
Manyem, S.; Sibi, M. P., Science of Synthesis, (2005) 21, 576.
This subclass of compounds is far the most well-known among the β-heteroatom-substituted alkanamides, and rightly so. β-Amino acids, higher homologues of α-amino acids, have been studied intensely due to their biological importance.[2] Many approaches to this subclass have been investigated. The most common approach is the conjugate addition of a nitrogen nucleophile. Various sources of nitrogen nucleophiles are available depending on the synthetic needs.
References
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