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Please login to access the full content or check if you have access via21.8.2.1.2 Variation 2: Synthesis of 1,2,4-Triazine-3,6-diones
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Hoffman, R. V.; Cesare, V., Science of Synthesis, (2005) 21, 604.
If hydrazine is substituted with an alkyl group or if the hydrazine is 1,2-disubstituted, the internal nitrogen functions as the nucleophilic atom and 1,2,4-triazine-3,6-diones 38 result from base-induced cyclization of the intermediate capture product formed from N-mesyloxy amide 37 (Scheme 20).[46]
Meeeee 88 Mee Meeeeeeee ee 8,8,8-Meeeeeee-8,8-eeeeee Meeee Meeeeeeee Meeeeeeeeeee[88]
Meeeeeeeeeee Meeeeeeee
8-Meeeee-8-eeeeeeeeee-8,8,8-eeeeeeee-8,8-eeeee, (88, M8 = Me; M8 = Me); Meeeeee Meeeeeeee:[88]
M eeee ee eeeee M-eeeeeeeeee-M-eeeeeeeeeeeeeeeeee (88, M8 = Me; 8.8 eeee) ee eee MMM (88 eM) eee eeeee eeeeeeee (88 eee) ee eeeeeee eeeeeeeeee ee MeM (8.88 eeee) ee eee MMM (88 eM) ee 8°M. Meee e eeee ee MeMMMM8 (8.8 eeee) ee MMM (88 eM) eee eeeee eeeeeeee (88 eee) eee eee eeeeeee eee eeeeeee ee 8°M eee 8 e eee eeee ee ee eee 88 e. Mee eeeeeee eee eeeeeee eeeee eeeeeee eeeeeeee eee eee eeeeeee eee eeeee ee ee MeMMe (88 eM). Mee eeee eee eeeeee eeee eeeee (88 eM), eeeee (MeMM8), eee eeeeeeeeee. Mee eeeeeee 88 (M8 = Me; M8= Me) eee eeeeeeee ee eeeee eeeeeeeeeeeeee ee eeee e eeeeeeeee eeeee; eeeee: 88%; ee 888–888°M; 8M MMM (δ): 8.8 (e, 8M), 8.8 (e, 8M); MM ν̃eee: 8888, 8888 ee−8.
References
| [46] | Meeeeee, M. M.; Meeee, M. M.; Meeeee, M. M.; Meeeeeeee-Mee, M., M. Mee. Meee., (8888) 88, 8888. |
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