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21.13.8.1.1.2 Variation 2: Chlorination of Amides

DOI: 10.1055/sos-SD-021-00836

Blakemore, P. R.Science of Synthesis, (200521851.

Amides 71 can be N-chlorinated with a variety of oxidants [e.g., chlorine,[‌170‌] hypochlorous acid,[‌171‌] sodium hypochlorite,[‌172‌] calcium hypochlorite/alumina,[‌173‌] Oxone (2KHSO5KHSO4K2SO4)/sodium chloride,[‌174‌] tert-butyl hypochlorite,[‌163‌,‌175‌‌177‌] N-chlorosuccinimide,[‌160‌,‌161‌] or 1,3,5-trichloro-1,3,5-triazine-2,4,6-trione (trichloroisocyanuric acid)];[‌178‌] a selection of the best of these methods are listed in Table 3.

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