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21.14.1.2.3 Method 3: Reduction of Acylphosphonates

DOI: 10.1055/sos-SD-021-00911

Whitehead, A.; Sieck, S. R.; Mukherjee, S.; Hanson, P. R.Science of Synthesis, (200521917.

It is known that α-hydroxy phosphonates serve as important functional groups in a number of biologically active systems.[‌33‌‌35‌] Since the discovery of amino α-hydroxy phosphonic acids,[‌36‌] there has been continued interest in the development of phosphorus-containing analogues of amino acids. One approach for stereocontrolled access to this class of compounds has been through the use of substrate- as well as reagent-controlled reductions of α-oxo phosphonates.

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