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Please login to access the full content or check if you have access via22.1.1.1.7.4.1 Variation 1: Phosphorus(III)-Substituted Sulfonium Ylides
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Aggarwal, V. K.; Richardson, J.; Winn, C. L., Science of Synthesis, (2005) 22, 49.
Since phosphonium salts bearing an additional strongly electron-withdrawing group are C—H acidic species, they can be used to generate sulfonium ylides bearing an α-phosphonium substituent. The reaction of phosphonium ylides with the Corey–Kim reagent 69 (generated in situ from dimethyl sulfide and N-chlorosuccinimide) at 0°C in dichloromethane affords dimethylsulfonium (triphenylphosphonio)methylide chlorides 111 in good yield (Scheme 70).[143]
Meeeee 88 Meeeeeeee ee α-Meeeeeeeeee-Meeeeeeeeee Meeeeeeee Meeeee eeee eee Meeee–Mee Meeeeee[888]
Mee eeeeeeee ee eeeeeeeeeee eeeeee eeee eeeeeeeeeeeeeeeeeeeeeeee eeeee (eeeeeeeee ee eeee eeee eee eeeeeeee ee e eeeeeeeee eeee eeeeee eeeeeeeee) eeee eeeeeeeeee e eeee eeeeeeeee eeeeee eee eee eeeeeeeee ee eee eeeeeeeeeeeeeeee eeeeeee(eeeeeeeeeeeeeeeeeee)eeeeeeeee eeeee 888 (Meeeee 88).[888]
Meeeee 88 Meeeeeeee ee α-Meeeeeeeeee-Meeeeeeeeee Meeeeeeee Meeeee eeee Meeeeeeee Meeeeeeeee[888]
Meee eeeeee ee eeee eeeeeeeeee ee eee eeeeeeeee ee α-eeeeeeeeeee-eeeeeeeeeee eeeeeeeee eeeeee eeeeeee ee eeeeeeeeee eeeeeeee-eeeeeeeeeee eeeee.
Meeeeeeeeeee Meeeeeeee
Meeeeeeeeeeeeeee Meeeeee(eeeeeeeeeeeeeeeeeee)eeeeeeeeee 888; Meeeeee Meeeeeeee:[888]
M eeeeeee eeeeeeeeee eee eeeeeeeeeee eeee (8.888 eee), MM8Me8 (88 eM), eee eeeeeeeee (8.888 eee), eee Me8M (8.888 eee) eee eeeeeeee. Mee eeeeeeee eee eeeeeeeee ee MMM eeeeeee eee eeeeeeeeeee eeee (MeMM/MMMe8 8:8). Mee eeeeeee eee eeeeeeeeeee ee e eeeeee eee eee eeeee eee eeeeeeeeeeee ee eeeeeeee ee eeeeee/Me8M (8:8). Mee eeeee eee eeeeeeeee ee eeeeeeeeee eee eeeeeeee ee eeeeeeeeeeeee eeee eeeeeee eeeee Me8M; eeeee: 88%.
References
| [126] | Meeeeeeeee, M. M.; Meeeeeeee, M. M., Me. Mee. Meee., (8888) 88, 888; Meee. Meeee., (8888) 88, 8888. |
| [143] | Meeeeeeee, M.; Meeüeee, M.; Möee, M., Meeeeeeee, (8888), 888. |
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