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Please login or sign up for a free trial to access the full content. Variation 2: By Microwave Irradiation with Lawesson's Reagent

DOI: 10.1055/sos-SD-022-00101

Glass, R. S.Science of Synthesis, (20052288.

A variety of 2H-1-benzopyran-2-thiones (e.g., 6), thionolactones, and thiocarboxylic O-acid esters can be advantageously synthesized in 7698% yields from the corresponding carbonyl compounds using Lawesson's reagent under microwave irradiation without any solvent (Schemes 4 and 5).[‌10‌] The advantages of this method over the usual thionation with Lawesson's reagent are faster reaction rates, higher yields, avoidance of dry solvents, and that the use of excess reagents is not required.

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