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Please login to access the full content or check if you have access via Variation 4: Addition of Ammonia or Amines to Nitriles Substituted with Electron-Withdrawing Groups

DOI: 10.1055/sos-SD-022-00489

Ostrowska, K.; Kolasa, A.Science of Synthesis, (200522386.

The reaction of nitriles containing strong electron-withdrawing groups in the α-position with ammonia or amines proceeds smoothly without a catalyst, at low temperature, to give the corresponding unsubstituted or N-substituted amidines in high yields.[‌33‌‌35‌] Typical examples are shown in Scheme 10 for the formation of 16 and 17.[‌34‌,‌35‌] See also HoubenWeyl, Vol. 5/3 p 307.

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