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23.10.4.1.1.2 Variation 2: Flash-Vacuum Pyrolysis of Meldrum's Acid Derivatives

DOI: 10.1055/sos-SD-023-00342

Kollenz, G.Science of Synthesis, (200623366.

Flash-vacuum pyrolysis at 600°C of Meldrum's acid derivatives 66, obtained from appropriate pyrazolamines and methoxymethylene Meldrum's acid, generates methyleneketene intermediates 67, which isomerize by [1,3]-hydrogen shift to the corresponding imidoylketenes 68, which then cyclize to pyrazolo[1,5-a]pyrimidinones 69 in 4853% yield (Scheme 20).[‌35‌]

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