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23.13.1.2.1 Method 1: [2+2] Cycloadditions Leading to 4-Alkenylcyclobutanones

DOI: 10.1055/sos-SD-023-00504

Danheiser, R. L.; Dudley, G. B.; Austin, W. F.Science of Synthesis, (200623506.

The [2+2] cycloaddition of a ketene with either an alkene or an alkyne provides a powerful method for the synthesis of a cyclobutanone or a cyclobutenone, respectively. The scope and limitations of these important processes are covered in several earlier reviews.[‌59‌‌61‌] Ketene [2+2] cycloadditions are also covered extensively in this volume of Science of Synthesis, particularly in the context of the synthetic applications of ketene Product Classes 36, 12, and 14, in Sections 23.323.6, 23.12, and 23.14, respectively.

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