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DOI: 10.1055/sos-SD-023-00535

Tidwell, T. T.Science of Synthesis, (200623572.

Carboxylic acids can be converted directly into ketenes by pyrolysis. This method can be applied in the preparation of ethylketene (3) labeled at the central carbon with carbon-11. The labeled ketene is captured in solution by the phorbol ether 13 to give the phorbol derivative 14 acylated with [1-11C]butanoic acid (Scheme 4).[‌50‌]

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