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24.2.10.1.6 Method 6: Elimination of Hydrogen Halides from Phosphorylated 1,2-Difunctionalized Compounds

DOI: 10.1055/sos-SD-024-00466

Heydt, H.Science of Synthesis, (200624451.

Phosphorus compounds with a 1-alkoxyalkyl substituent, bearing further substituents at the 1- or 2-positions that are capable of undergoing elimination, are suitable starting materials for 1-phosphorus-functionalized 1-(organooxy)alkenes. These starting compounds are often generated in situ and subjected directly to the elimination process. For example, the reaction of acyl bromides with triphenylphosphine yields the [1-(acyloxy)alk-1-enyl](triphenyl)phosphonium bromides 52 (Scheme 20).[‌53‌]

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