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24.2.10.2 Applications of Product Subclass 10 in Organic Synthesis

DOI: 10.1055/sos-SD-024-00466

Heydt, H.Science of Synthesis, (200624456.

[(1-Hydroxy)alkyl]phosphonates are potent inhibitors of enzymes. The catalytic asymmetric hydrogenation of 67 using a chiral rhodium catalyst gives, after hydrolytic removal of the benzoyl substituent, the desired [(1-hydroxy)alkyl]phosphonates 68 (Scheme 29).[‌80‌,‌81‌]

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References


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