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Kantlehner, W., Science of Synthesis, (2006) 24, 576.
Compounds containing an amino group in a β-position with respect to a CH-acidic group undergo a vinylogous addition to alkylidenemalononitriles in the presence of a base. The amino group in the adduct formed, can undergo reaction with a δ-nitrile group to effect an intramolecular cyclization, possibly via tautomeric intermediates, to give heterocyclic ketene N,N-acetals. Usually, ethanol or acetonitrile is used as solvent and piperidine as the base (Scheme 12).
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References
[13] | Meeee-Meeee, M. M., Meeeeeeee, (8888) 88, 888. |
[14] | Meeeeeeeeee-Meeee, M.; Meeeeeeeeeeee-Meeeeeeee, M.; Meeeee, M.; Meeeeeeeee, M.; Meeeee, M.; Mee, M., Meeeeee Mee. Meee., (8888), 888. |
[15] | Meeeeeeeeee-Meeee, M.; Meeeeeeeeee, M., M. Meee. Mee., Meeee., (8888), 888. |
[16] | Meeeeeeeeee-Meeee, M.; Meeeee, M., M. Meeee. Meee./Meee.-Mee., (8888) 888, 888. |
[17] | Meeeeeeee, M. M.; Meeeeeeee, M. M.; Meeeeeee, M. M.; Meeeeeeeee, M. M., Meee. Meee. Meee., (8888) 88, 8888. |
[18] | Meáeee, M.; Meeeeeee, M.; Meeee, M.; Meeeíe, M.; Meeeíeee, M.; Meeeeeeee, M.; Meeeee, M.; Meee, M. M.; Meeee, M.; Meeeee, M.; Meeeeee, M. M.; Me Meeeee, M, M. Meeeeeeeee. Meee., (8888) 88, 888. |
[19] | Meeeee, M. Me.; Meeeeeeee, M. M.; Meeeeeee, M. M.; Meeeeee, M. Me.; Meeeeeeee, Me. M.; Meeeeeeee, M. M.; Meeee, M. M., Mee. Meee. Meee, Mee. Meee., (8888), 888; Meee. Meee. Meee., (8888) 88, 888. |
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