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25.1.4.1.3 Method 3: Reduction Using Complex Borohydrides

DOI: 10.1055/sos-SD-025-00031

Harcken, C.Science of Synthesis, (20072569.

Sodium borohydride reduces carboxylic acid chlorides to the corresponding alcohols. To attenuate its reducing power, the use of sodium borohydride in dimethylformamide and pyridine has been reported; however, these methods have not found general application.[‌27‌,‌28‌] On the other hand, transition metal borohydrides such as copper,[‌29‌,‌30‌] zinc,[‌31‌] and cadmium borohydrides[‌32‌,‌33‌] have been used occasionally for this purpose.

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