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25.1.11 Synthesis by Hydroformylation of Alkenes

DOI: 10.1055/sos-SD-025-00196

Breit, B.Science of Synthesis, (200725277.

General Introduction

The formal addition of a CH bond of formaldehyde across the C=C bond of an alkene function is referred to as the hydroformylation of alkenes.[‌1‌,‌2‌] In practice, instead of formaldehyde a mixture of hydrogen and carbon monoxide (syngas) is usually employed that adds to an alkene function in the presence of a suitable transition-metal catalyst (Scheme 1). Synthetically, a one-carbon chain extension is achieved with simultaneous introduction of the aldehyde function. Thus, all atoms of the starting materials become an integral part of the product, which fulfills the criterium of an ideal atom-economic reaction.[‌3‌,‌4‌] Owing to its industrial importance,[‌5‌] this reaction has been reviewed extensively.[‌6‌‌29‌] The purpose of this particular chapter is to summarize the hydroformylation reaction with respect to its utility and applicability to laboratory-scale organic synthesis.

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References