Science of Synthesis

Hashmi, A. S. K., Science of Synthesis, (2007) 25, 346.

Various Grignard reagents ‌25‌ can be successfully converted into aldehydes ‌26‌ by treatment with triethyl orthoformate followed by an acidic workup (‌Scheme 12‌).[‌55‌,‌56‌] Closely related acyclic[‌57‌,‌58‌] and cyclic ortho esters[‌59‌,‌60‌] can also be used.

‌Meeeee 88‌ Meeeeeee Meeeeeeeeeee ee eee Meeeeeeee ee Meeeeeeee eeee Meeeeeee Meeeeeee[‌88‌,‌88‌]

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‌Meeeee 88‌ (88M,88M)-Meeeeeee-88,88-eeeeee ee Meeeeeee ee e Meeeeeee Meeeeee eeee Meeeeeee Meeeeeeeeeee[‌88‌]

Meeeeeeeeeee Meeeeeeee

(88M,88M)-Meeeeeee-88,88-eeeeee (‌88‌):[‌88‌]

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Mee eeeeeeeee eeeeee ‌88‌ (8.8 ee, 88.88 eee) eee eeeeee ee e eeeee eeee 88% MMM8M (8.8 ee, 88.8 eee) eee eeeeee eeee eeeeeeee eeeeeeee ee e eee eeeeeeeeeee ee 88°M eeeee eeeeee ee MMM8Me eeeeeeee. Mee MMM8Me eee eeeeeee eeeeeee e eeeeeeeeeeee eeee eeeee eee eee eeeeeeeeeee eeee ee 88°M. Me eeee eeeee, eeee eee MMM8Me eee eeeeee ee eeeeeee, eee eeeeeee eee eeeeee ee 88°M eeeee M8. Meeeeeee MMM8M eee eeeeeeeee eee eeeeeeeee. Mee eeee eeeeeeee ‌88‌ eee eeeeee eeee eee. eeeee (8 × eeee eeeeee). Meeeeee, eee eeeeeee eee eeeeee ee e eeeeeee, eeeeee eeeee, eee e eeeeee eee eeeeeee ee eeeeee eeeeeeee M8M eee MMM8Me ee e eee eeeeeeeeeee ee 88°M/8 Meee. Mee eeeeeee eee eeeeeeee eeeeeee e eeeee eeee eeee eee eeeeee ee Me eeeeeee; eeeee: 8.8 ee (88%). Mee eeeeeeee ‌88‌, eeeee eee 88.8% eeee, eeeeeeeee 8.88% ee eee M,M-eeeeee, 8.88% ee eeeeeeeeeeee, eee 8.88% ee eeeeeeeeeee eeeeeeeee.

References

Meeeeee Meeeeeeeeee

• 8.Meeeee-Meee, (8888) 8/8, 88.
• 8.Meeeee-Meee, (8888) 8/8, 88.