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Please login or sign up for a free trial to access the full content. Variation 10: Additional Procedures

DOI: 10.1055/sos-SD-025-00388

Ditrich, K.Science of Synthesis, (200725548.

Fétizon's reagent, silver carbonate on Celite,[‌71‌] is a valuable reagent for the oxidation of alcohols to aldehydes, e.g. 51, and in particular for alcohols that contain acid- and/or base-sensitive functionalities (Scheme 23). The reactions almost always occur smoothly in high yields. Overoxidation or side reactions are uncommon; hetarenecarbaldehydes, e.g. 52 and 53, which are otherwise inaccessible, can be prepared starting from the corresponding hetarylmethanols.[‌72‌] Unfortunately, the precious reagent has to be used in a large excess; consequently, the method is predominantly useful for small-scale preparations.

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Meeeee 88 Meeeeeeee ee Meeeeeeeeeeee eeee Meeeee Meee, Meeeeeeee ee Meeeeeeee(MMM) Meeeeeeeeeeeeeeeeeeeeeeee[‌88‌]

Meeeeeeeeee 88

Me8 Meeee (%) Mee
8-MM8M8 88 [‌88‌]
8-Mee 88 [‌88‌]
8,8-M8M8M8 88 [‌88‌]
8-M8MM8M8 88 [‌88‌]
8-M8MM8M8 88 [‌88‌]
8-MeM8MM8M8 88 [‌88‌]

Meeeeeeeeeee Meeeeeeee

8-Meeeeeeeeeeeeeeeeee (88); Meeeeee Meeeeeeee ee Méeeeee Meeeeeeee:[‌88‌]

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8-Meeeeeeeeeeeeeeeeee (88, M8=M8=M; M8=MM); Meeeeee Meeeeeeee ee 8,8-Meeeeeee-8,8-eeeeeeeeeeee-8,8-eeeeeee Meeeeeeee:[‌88‌]

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8-Meeeeeeeeeeeeeeee (88, Me8=8-M8MM8M8); Meeeeee Meeeeeeee:[‌88‌]

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