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25.6.6 Synthesis by Formylation of Arene—Hydrogen Bonds

DOI: 10.1055/sos-SD-025-00443

Schall, A.; Reiser, O.Science of Synthesis, (200725605.

General Introduction

Aromatic aldehydes belong to one of the most important classes of compounds and are used as starting materials for a great number of chemical processes. Although the need for developing efficient methodology from readily available arenes was recognized more than 100 years ago, the synthesis of these compounds by direct formylation of arenes remains challenging. Only a few methods equivalent to FriedelCrafts ketone synthesis by acylation are known, because, in contrast to other carboxylic acids, activated derivatives such as halides and anhydrides of formic acid are considerably less stable and much less available (Scheme 1).[‌1‌]

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References


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