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26.1.1.2.2.2 Variation 2: With Chromic Acid in Acetic Acid

DOI: 10.1055/sos-SD-026-00003

von Angerer, S.Science of Synthesis, (20052644.

Addition of acetic acid to chromic acid or chromic/sulfuric acid mixtures often has a favorable effect on oxidation reactions due to an increased solubility of the reactants. Alternatively, chromium(VI) oxide is dissolved in acetic acid to afford a mixed anhydride as the oxidizing reagent. One of the early examples of this procedure is the preparation of ­tropinone (15) from tropine (14) (Scheme 10).[‌57‌]

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