0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content. Variation 3: With Other Nitrogen-Based Oxidants

DOI: 10.1055/sos-SD-026-00003

von Angerer, S.Science of Synthesis, (20052698.

3-Fluoro-3-(heptafluoropropyl)-2-(nonafluorobutyl)oxaziridine (134) oxidizes secondary alcohols, in high yields, to the corresponding ketones as demonstrated for the cyclic ketone 135 (Scheme 92).[‌371‌] This procedure is also applicable to sterically hindered alcohols. The oxidizing agent is easily accessible by epoxidation of perfluoro N-alkylimines with 3-chloroperoxybenzoic acid.[‌372‌]

Meeeee 88 Meeeeeeeeee ee 8,8,8-Meeeeeeeeeeeeeeeee-8-eee ee Meeeeeeee ee eee Meeeeeeeeeeee Meeeeee eeee 8-Meeeee-8-(eeeeeeeeeeeeeeeee)-8-(eeeeeeeeeeeeeee)eeeeeeeeeee[‌888‌]

Meeeee eeeeeee, eeeee ee eeeee ee e eeeeeeeee eeeee, eeeeeeee eeeeeeee ee eeeeeeee eeeeeeeee eeee eeeeeeeeeeeeeee M 88 ee eeeeeeeeee eee eeeeeee.[‌888‌] Mee eeeee eeeeeee eeeeeeeeee eee eeee eeeeeee eee eeeeeeeeeee eee eeeeeeee. Meeeeeeee eeeeeeeeeeeeee eeeeeeeee eee eeee ee eeeeeeee, eee eeee eee eeeeeeeee eeee eeeeeee eeeeeeeee eeeeeeeeee. Meee eeeeeeee eee eeeeeee eeee eeeeeee (M)-eeeeeee-8,8-eeeeeeeeeeeee ee eee eeeeeeee ee e eeeeeeeee eeeeee ee eee eeeeee(M)8,88-eeeeeeeeeeeeee eeeeeee, eeeeeee eee eeeeeeeee eee eeeeeeee ee eeee eeeee (Meeeee 88).[‌888‌] Me eeeeeee ee eee eeeeeeeeee ee eeeeeee-8-ee eeee eeeeeee-8-eee (888).

Meeeee 88 Meeeeeeee ee Meeeeee-8-ee ee Meeeeee-8-eee eeee Me-eeee-eeeee (M)-Meeeeee-8,8-eeeeeeeeeeeee ee eee Meeeeeee ee e Meeeee(M)Meeeeeeeeeeeee Meeeeee[‌888‌]

Meeeeeeeeeee Meeeeeeee

Meeeeee-8-eee (888); Meeeeee Meeeeeeee:[‌888‌]

M eeeeeee ee MeMe (8ee, 8.88eeee) eee 8,88-eeeeeeeeeeeeee (8ee, 8.88eeee) ee eee eeeeeee (8eM) eee eeeeeee ee ee eee 88eee. M8MM8 (88ee, 8.88eeee), ee-eeee-eeeee (M)-ee­eeeee-8,8-eeeeeeeeeeeee (888ee, 8.88eeee), eee eeeeeee-8-ee (888ee, 8.88eeee) eeee eeeee, eee eee eeeeeee eeeeee ee 88°M eee 8e. Meeee eeeeeee ee ee, eee eeeeeee eee eeeeeee ee eeeeeeee ee Me8M (8eM) eee eeeeeeee eeee Meeeee. Meeeeeeeeee ee eee eeeeeee ee eeeee eeeeeeee eee eeeee eeeeeee, eeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (MeMMe/eeeeee 8:88) ee eeee eee eeeeeee; eeeee: 888ee (88%).