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Please login or sign up for a free trial to access the full content. Method 2: From Amines

DOI: 10.1055/sos-SD-026-00003

von Angerer, S.Science of Synthesis, (200526115.

The conversion of primary amines at a secondary carbon atom to the oxo group is a common reaction in biochemistry. Examples are the oxidative deamination of glutamate and transamination reactions which lead to the formation of α-oxocarboxylic acids. Preparative methods for the transformation of amines to ketones, e.g. 170, comprise the oxidation with potassium permanganate (Table 12, entry 1),[‌465‌,‌466‌] iodosylbenzene (Table 12, entry 3),[‌467‌] hydrogen peroxide in the ­presence of bromine,[‌468‌] N-(tert-butyl)benzenesulf­in­imidoyl chloride (Table 12, entry 5),[‌469‌] peroxydisulfate (Table 12, entry 4)[‌470‌] and 3,5-di-tert-butylbenzo-1,2-quinone (Table 12, ­entry 6).[‌471‌]

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