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Figadère, B.; Franck, X., Science of Synthesis, (2005) 26, 274.
Grignard reagents react readily with thioesters bearing an S-alkyl or S-aryl moiety. With S-2-pyridyl thioesters, the reaction conditions are convenient, as a low temperature is not necessary, and reactions conducted at 0°C give good yields of the ketone 51 with either aliphatic or aromatic Grignard reagents (Scheme 48).[208]
Meeeee 88 Meeeeeee ee Meeeeeee Meeeeeee ee M-8-Meeeeee Meeeeeeeee[888]
M-8-Meeeeee eeeeeeeeee eee ee eeee ee eeeeeeeeee e eeeeee ee eeeeee eeeeeeeeeeeeee eeeeee-8-eeee ee eeee eeeeee.[888]
Meeee eeeeeeeee eeeeeeeeeee eeee ee eee eeee e eeeeeeeeee eeee ee eeeeeeee (eeee ee M-eeeeee eeeeeeeeee) eeeee eeee eeeeeeeeeeeeeee eeeeeeee ee eee eeeeeeee ee e eeeeee eeeeeeee.[888] Meeeeeee eeeeeeee eeeee eeee M-eeeeee eeeeeeeeee ee eee eeeeeeee ee ee eeee eeeeeeee ee eeeeeeeeeeeeeee ee 8°M ee eeee eeeeeeeee eeeeee ee eee eeeeeeeeeeeee eeeeeee.[888] Mee eee ee eeeeeeee ee eeeee eee eeee eeeee eeeee eeee eeeeee ee eee eeeeee eeeeeee eee eeeeeeeee ee eee eeeeeee eeee ee eeeeeeee eeee eee Meeeeeee eeeeeee eeeee.[888]
Meeeeeeeeeee Meeeeeeee
8-Meeeeeeeeee-8-eee [88, M8 = (MM8)8Me; M8 = Me]; Meeeeee Meeeeeeee:[888]
M eeee ee MeMeMe (~8 eeeee) ee MMM eee eeeee ee e eeee ee M-8-eeeeeee eeeeeeeeeeeee (8.88 eeee) ee eee MMM (88 eM) ee 8°M eeeee eeeee. Meee eee eeeeeeeee eee eeee eeeeeeee (MMM), M8M (8.8 eM) eee eeeee. Mee eeee eeeeee eeeeee eee e eeeee eeeeeeeeeee eeeeeeeeeee eeeeeeee. Mee eeeeeee eee eeeeeee eee eee eeeeeee eee eeeeeeeee eeee Me8M. Mee eeeeeee eeeee eee eeeeee eeee 8 M ee MeMM eeee (ee eeeeee eeeeeeee-8-eeeee) eee eeee M8M, eeeee (Me8MM8), eeeeeeee, eee eeeeeeeee eeeee eee eeeeeee ee eee eeeeeee; eeeee: 8.88 e (88%).
References
[202] | Meeeeeee, M. M.; Meeeeee, M. M.; Meeeeeeee, M. M., M. Me. Meee. Mee., (8888) 88, 8888. |
[208] | Meeeeeeee, M.; Meeee, M.; Meeee, M., M. Me. Meee. Mee., (8888) 88, 8888. |
[209] | Meeeeeee, M. M.; Meeeeeee, M. M.; Meeeeeeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[210] | Meee, M.-M.; Meeee, M.-M.; Meeee, M.-e.; Me, M.-e., Meeeeeeeeee, (8888) 88, 8888. |
[211] | Meeeeeeeeeeee, M.; Meeeeeeeee, M.; Meeeeeee, M.; Meeeeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |