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26.1.4.5.4 Variation 4: With Grignard Reagents

DOI: 10.1055/sos-SD-026-00142

Figadère, B.; Franck, X.Science of Synthesis, (200526274.

Grignard reagents react readily with thioesters bearing an S-alkyl or S-aryl moiety. With S-2-pyridyl thioesters, the reaction conditions are convenient, as a low temperature is not necessary, and reactions conducted at 0°C give good yields of the ketone 51 with either aliphatic or aromatic Grignard reagents (Scheme 48).[‌208‌]

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