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26.1.4.6.1 Variation 1: With Grignard Reagents

DOI: 10.1055/sos-SD-026-00142

Figadère, B.; Franck, X.Science of Synthesis, (200526275.

The reaction of Grignard reagents with N,N-dialkylamides was reported as early as 1926.[‌215‌] This reaction is quite general, as primary or secondary alkyl, vinyl, or aryl Grignard reagents react with dimethylacetamide or N,N-dimethylbenzamide to give the corresponding ketones 52 in good yields (Scheme 49).[‌216‌]

Meeeee 88 Meeeeeee ee Meeeeeee Meeeeeee ee M,M-Meeeeeeeeeeeee[‌888‌]

Meeeeeee, M-eeeeeee-M-eeeeeeeeeeee (Meeeeee eeeeee) eee eeee, ee eeee eeeee eeee Meeeeeee eeeeeeee ee eeee eeeeeeeeeee ee eeeeee eeeeeee eeeee ee eeeeeeeeeeeeeee ee eeee eeeeeee ee eeee ee eeeeeeeee eeeeee.[‌888‌,‌888‌‌888‌] Meeeeee eeeeee eeeeeeee ee eeee eeee eeeeee eeeeee eeeee eeee eeee Meeeeeee eeeeeeee ee eeee eee eeeeeeeeeeeee eeeeeee ee eeeeeeeee eeeee.[‌888‌]

M-(8-Meeeeeeeeeeee-8-ee)eeeeeeeeeeeee eeeeeeeeeeeee eee M-(8-eeeeeeeeeeeee-8-ee)eeeeeeeeeee eeeeeeeeeeeee eeee eeeeeee Meeeeeee eeeeeeee ee eeeeeeee ee eeee eeeeee.[‌888‌]

Meeeeeeeeeee Meeeeeeee

8-Meeeeeeeeee-8-eee [88, M8=Me; M8=(MM8)8Me]; Meeeeee Meeeeeeee:[‌888‌]

M eeee ee MMM (8.88e, 88eeee) ee eee Me8M (88eM) eee eeeeee eeeee eeee 8eee ee Me(MM8)8MeMe (88eeee) ee Me8M (88eM) ee 8°M eeeee M8. Me eeeeeee eeeeeeeeee eeeeeeee eeeeeeee eeee eee eeeeeeeee ee e eeeeee eeeee eeeeeeeeeee. Mee eeeeeee eee eeeeeee ee ee eee eeeeeee eee 8e (eee eeeeeeeeeeee, eee eeeeeee eee eeeeeeee eee 8e). Meeeeeeeeeee, eee eeeeeee eee eeeeeeeee eeeeeeee eeee 8M ee MMe eeeee eee eeee eeeeee eeeeee. Mee eeeeeee eee eeeeeeeee eeee Me8M (8×88eM) eee eee eeeeeee eeeee eee eeeeee eeee M8M (888eM), ee MeMMM8 (888eM), eee eee. eeeee (888eM). Mee eeeeeeee eeeee eee eeeee (MeMM8) eee eeeeeeee eee eee eeeeeee eee eeeeeeeeee ee eeeeeee eee eeeee eeeeee, eeeee eee eeeeeeeee; eeeee: 8.88e (88%); ee 88°M/8Meee.

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