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26.1.5.3 Method 3: Hydroacylation of Aldehydes

DOI: 10.1055/sos-SD-026-00198

Figadère, B.; Franck, X.Science of Synthesis, (200526295.

Hydroacylation is a powerful method for converting an aldehyde into a ketone. It is usually catalyzed by transition-metal complexes such as those of rhodium, cobalt, and ruthenium. The generally accepted mechanism is the formation of a hydrido acyl metal intermediate that undergoes addition to the double bond of an alkene to give an alkyl acyl metal species (Scheme 5). Reductive elimination affords the corresponding ketone. As in the radical reaction, the main side reaction is the decarbonylation of the acyl metal species to give an alkane product.

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