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Figadère, B.; Franck, X., Science of Synthesis, (2005) 26, 404.
Terminal alkynes are easily hydrated to the corresponding methyl ketones 6 in the presence of iron(III) complexes in dichloromethane at room temperature (Scheme 7).[23] Phenylacetylene gives the expected acetophenone in good yield, whereas aliphatic terminal alkynes afford the methyl ketones in moderate (ca. 50%) yields. Internal alkynes give mainly side reactions.
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References
[23] | Meeeeee, M.-M.; Meeeee, M., M. Meeeeeeee. Meee., (8888) 888, 888. |