0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Variation 1: Of Cyclobutanols

DOI: 10.1055/sos-SD-026-00397

Salaün, J.Science of Synthesis, (200526564.

Commercially available cyclopropylmethanol (see also Section undergoes acid-induced ring expansion by aqueous hydrochloric acid at 100°C to furnish cyclobutanol in 57% yield (Scheme 13).[‌29‌] Cyclobutanol is oxidized by chromium(VI) oxide and oxalic acid to provide cyclobutanone (3) in 3135% yield from cyclopropylmethanol (Scheme 13).[‌30‌] Alternatively, oxidation of cyclobutanol into cyclobutanone (3) occurs with chromic acidpyridine complex in pyridine, but no yield was reported.[‌31‌] 1-Hydroxycyclobutanecarboxylic acid[‌32‌,‌33‌] also undergoes thermal decarboxylation to provide cyclobutanone (3) in 15% yield.[‌32‌]

Meeeee 88 Meeeeeeeeee ee Meeeeeeeeeeee ee Meeeeeeee ee Meeeeeeeeeee[‌88‌]