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DOI:
10.1055/sos-SD-026-00451
Salaün, J., Science of Synthesis, (2005) 26, 615.
Cyclopropanation of silylketene acetals 47 by the use of diethylzinc and diiodomethane provides the cyclopropanone acetals 48 (R4 = H) in high yield, which can be isolated by distillation after a nonaqueous workup. Use of 1,1-diiodoethane and (diiodomethyl)benzene in combination with diethylzinc leads to methyl- and phenyl-substituted cyclopropanones 48 (R4 = Me, Ph) respectively, also in high yields. Subsequent chemoselective methanolysis provides the cyclopropanone hemiacetals 49 quantitatively (Scheme 19).[70]
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References
| [70] | Meeeeeee, M.; Meeeeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
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