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Please login to access the full content or check if you have access via Variation 11: Via a Preformed Enamine

DOI: 10.1055/sos-SD-026-00761

Suffert, J.Science of Synthesis, (200526890.

The chlorination of ketones through their enamines has not been extensively studied and has its limitations. Nevertheless, symmetrical ketones afford chloro ketones 63 via reactions between the enamines 62 and hexachloroacetone (as a positive chlorine source) in tetrahydrofuran at temperatures between 78 and 0°C (Scheme 27).[‌68‌]

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