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Suffert, J., Science of Synthesis, (2005) 26, 953.
Previously published information regarding this product class can be found in Houben–Weyl, Vol. 7/2c, p 2251. Although the synthesis of α-amino ketones is important because they can be used to form biologically active β-amino alcohols and related compounds,[230,231] direct methods for their preparation are few, and none exist that start from an aliphatic ketone. However, an indirect approach depends upon the Neber rearrangement of O-tosylated ketoximes to give amino ketones.[223–228] This technique was the first of its kind and it has been supplemented by several more modern alternatives. For example, nonaromatic α-amino ketones are obtained by the oxidative amination of O-silylated enols,[232] amination of α-bromo ketones,[233–235] from aldehydes and iminium salts,[236] from amino acids,[238] esters,[239] amides,[240] or acyl cyanides,[241] or directly from amines.[242]
References
[223] | Meeee, M. M.; Meeeeeeeeee, M., Meeeee Meeeeee Mee. Meee., (8888) 888, 888. |
[224] | Meeee, M. M.; Meeeeee, M.; Meeee, M., Meeeee Meeeeee Mee. Meee., (8888) 888, 888. |
[225] | M'Meeee, M., Meee. Mee., (8888) 88, 88. |
[226] | Meeeee, M. M.; Meeeee, M. M.; Meeee, M. M. M., M. Mee. Meee., (8888) 88, 888. |
[227] | Meeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[228] | Meeeeeeeee, M. M., Meeeeeee, M. M.; Meee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[230] | Meeee, M. M.; Meee, M. M.; Meeee, M. M.; Meeeee, M. M., M. Mee. Meee., (8888) 8, 88. |
[231] | Meeeee, M. M.; Meeee, M. M.; Meee, M. M.; Meeee, M. M.; Meeee, M. M.; Meeeee, M. M.; Meee, M. M., M. Mee. Meee., (8888) 88, 888. |
[232] | Meeeee, M.; Meeeeee, M., Meeeeeeeeee: Meeeeeeee, (8888) 8, 8888. |
[233] | Meeeee, M.; Meeeeeeeeee, M. M.; Meee, M.; Meeeee, M.; Meeeeeeeee, M. Me.; Meeeeeeee, M.; Meeeeee, M.; Meeeee, M., Meee. MMM Meeee. Meee. Meeeee, Mee. Mee., (8888), 888; Meee. Meeee., (8888) 888, 888888. |
[234] | Meeeee, M.; Meeeeeeee, M. M.; Mee Meee, M., M. Mee. Meee., (8888) 88, 8888. |
[235] | Meeeeeee, M.; Meee, M.; Meeeee, M.; Meeeeeee, M., M. Mee. Meee., (8888) 88, 8888. |
[236] | Meeeeeee, M.; Móeee-Meeeeeeee, M.; Meeeeeee, M.; Meeeee, M., Meeeeeeee, (8888), 888. |
[238] | Meeeeee, M. M.; Meeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[239] | Meeeee, M. M.; Meeeee, M. M. M.; Meeeeee, M. M.; M'Meeee, M.; Meeeeeee, M. M.; Meeeee, M. M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[240] | Meeeeeeee, M.; Meeeeeee, M.; Meeee, M.; Meeeee, M.; Meeeeeeee, M.; Meeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[241] | Meeeee, M.; Meeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[242] | Meeeeeeeee, M. M.; Meeeeeee, M. M., M. Me. Meee. Mee., (8888) 88, 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8e, 8888.