Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via
26.8.1.1.3.3 Variation 3: Aryl Grignard Reagents

DOI: 10.1055/sos-SD-026-00912

Campagne, J. M.; Six, Y.Science of Synthesis, (200526999.

The (noncatalyzed) reaction of acyl halides with aryl Grignard reagents has long been known to lead to the corresponding tertiary alcohols.[‌119‌] There is no major difference between aryl Grignard and other alkyl Grignard reagents (Section 26.1.4). Among the various efficient acyl halide surrogates (thioesters, acylimidazoles, mixed anhydrides; see Section 26.1.4), Weinreb amides[‌134‌] are probably the most widely used.[‌135‌,‌136‌] Moreover, it has been recently shown that esters can be directly converted into the corresponding ketones through the in situ formation of the Weinreb amide, as illustrated in Scheme 14.[‌137‌]

Meeeee 88 Meeeeeeee ee Meeeeee Meeeee eeee Meee Meeeeeee Meeeeeee[‌888‌]

Meeeeeeeeeee, ee eee eeee eeeee eeee eeee[‌888‌] ee eeeeee[‌888‌] eeeeeeeee eeeeeeeeeee eeeeeeee eee eeeeeeeeee ee eeee eeeeeee eeee eeee eeeeeee ee eee eeeeeeee ee eeee Meeeeeee eeeeeeee (Meeeee 88).[‌888‌] Mee eee ee eeeeeeeeeeeeee eeeeeee ee e eeeeeeeee eee eeee eeee eeeeeeee.[‌888‌]

Meeeee 88 Meeeee-Meeeeeeee Meeeeeeee ee Meee Meeeeeee Meeeeeee eeee Meee Meeeeee[‌888‌]

References


Cookie-Einstellungen