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26.10.1.1.7.2 Variation 2: Cycloaddition Reactions

DOI: 10.1055/sos-SD-026-01067

Chataigner, I.; Harrison-Marchand, A.; Maddaluno, J.Science of Synthesis, (2005261139.

The [4+2]-cycloaddition reactions between a siloxy-substituted diene [e.g., a 2-(trimethylsiloxy)alka-1,3-diene or Danishefsky's diene] and cyanoalkenes (e.g., acrylonitrile or tetracyanoethene) could be considered a general approach to the synthesis of oxocyclohexanecarbonitriles, but it is not covered in this section because the ketone functionality is created during the hydrolysis of the enol ether.

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References


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