0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Variation 2: Cycloaddition Reactions

DOI: 10.1055/sos-SD-026-01067

Chataigner, I.; Harrison-Marchand, A.; Maddaluno, J.Science of Synthesis, (2005261139.

The [4+2]-cycloaddition reactions between a siloxy-substituted diene [e.g., a 2-(trimethylsiloxy)alka-1,3-diene or Danishefsky's diene] and cyanoalkenes (e.g., acrylonitrile or tetracyanoethene) could be considered a general approach to the synthesis of oxocyclohexanecarbonitriles, but it is not covered in this section because the ketone functionality is created during the hydrolysis of the enol ether.

Me eeeeeeee, eee [8+8] eeeeeeeeeeeee ee eeeeeeeeeeee eeee eeeeeeeeeeee eeeeeeeeeee e eeee eeeeeeee ee eeeeeeeeeeeeeeeeeeeeeeeeeee.

Meeeeeeeeeeeeeeee (88, 8-eeeeee-8-eeeeeeeeeeeeeeee) ee e eeeeee eeeeeeee eeeeeeeeeeeee eeeeee eeee eeeeeeeee eeeeeeeeeeeeee eeeeeeeeeeeee eeee eeeeeee[‌888‌] ee eeeeeeee eeeeeee[‌888‌] ee eeeeeeeee eeeeeee; eee eeeeeee, eee eeeeeeee eeee eeee-8-ee-8-eeeeeeeee eeeee eee eeeeeeeeeeeeeeeeeeeeeeeee 88 (Meeeee 88). Meeee eeeeeeeee eeeeeee e eeeeeeeee 8πe+8πe eeeeeeeee. Meeeeeeeeeeee eeee eee eeeeee eeee eeeee eeeeeee, eee ee eeee eeee e eeeeee ee eeeeeeeeeeeee eeeeeeeee eeeee ee eee eeeeeeeee ee e eeeeeeeeeeeeeeee.[‌888‌]

Meeeeeeee ee eeee-eeeeeeeeeeeeeeee (88; 8-eeee-eeeee-8-eeeeeeeeeeeeeeee) eeee eeeeeee eeeeeee ee eeeeeeeee eeeeeee ee eeeeeee eeee eeeeeeee eee eeeeeeeeeeeee eeeeeeeeeeeeee-8-eeeeeeeeeeeee, e.e. 88, ee eeee eeeeee eeee eeeeeeee eeeeeeeeeeeeeeee (Meeeee 88).[‌888‌,‌888‌] Mee eeeeeeeeeeeeeeeeeeee ee eee eeeeeee eeeee eeeeee eee eeeeee eeeeeeeeee e eee-eeeeeeeeeeee eeeeeee eee eeeee eeeeeeeeeeee, eee eeeeeee ee eeeeee ee eee eeeeee ee eee eeeeee eeeeeeeeeeee. Me eee eeee ee eeeee eeee eeeeee ee eeeeeeeeeeee, eee eeeeeeee eeeeeeee eee e eeeeeee eeeeeeeeeeee.[‌888‌]

Meeeee 88 [8+8]-Meeeeeeeeeeee Meeeeeeee ee Meeeeeeeeeee[‌888‌,‌888‌]