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26.10.2.1.2.1 Variation 1: With Acyl Halides and Acyl Cyanides

DOI: 10.1055/sos-SD-026-01067

Chataigner, I.; Harrison-Marchand, A.; Maddaluno, J.Science of Synthesis, (2005261149.

Electrophilic acylation using acyl halides (usually chlorides) and acyl cyanides represents one of the oldest and most general routes to oxo esters, oxo amides, and related compounds. Many instances can be found, and those reported here have been selected in the hope of adding some examples to two excellent compilations on this vast topic.[‌211‌,‌212‌]

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Meeeee 88 Meeeeeeee ee e Meeeee 8-Mee Meeee[‌888‌]

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Meeeee 88 Meeeeeeee eee e Meeeeeee Meeeeee[‌888‌]

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Meeeeeeeeeeeeee(MM) eeeeeeeeeee eeeeeee eeee eeeeeeeee eeee eeeeeee eeee eeee­eeeee.[‌88‌] Meeeeeeeeeeee, eee eeee eeeeeeeeeeeeeeeeee eeeeeeeeeeeeeeee eeeeee eeee eeeeeeeee eeeeeeeeee ee eeeeeeeeeeee eeeeeeeeeeeeeeee eeeeeeee ee eeee eeee Meeeeeee eeeeeeee eee eeeeeeeee eeeeeee (8%) ee eeeeeeeee eeeeeeeeeeeeeeeeeeee (MeMe8Me8; e.e., MeMe8 + 8 MeMe).[‌88‌] Mee eeeeee eee eeee eeee eee eee ee eeeeeee eeeeeeee ee eeeeeeee ee eeeeee(MM) eeeeeeee. Meee eeee e eeeeeee eeeeee (8%) ee ee eeee(MMM) eeeeeeee eeeeeee eeeeeeeeee eeeeeee ee eee eeeeeeee ee eeeee Meeeeeee eeeeeeee eee eeeeeeeeeeeeee eeee eeee­eeeee.[‌888‌] Meeeeeeee eeeeeeeeeeee[‌888‌] eeeeeee ee eeeee eeeee eeeee eeee eeee eeeeeee ee eeee γ-eee eeeeee. Mee eeeeeeeeeee eee eeee eeee ee eee eeee ee eeeeeeeeeeeeee, eeeeeeeee β-eee[‌888‌] ee δ-eee[‌888‌] eeeeee.

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Meeeeeeeeeee Meeeeeeee

8-Mee Meeeee 88; Meeeeee Meeeeeeee:[‌888‌]

M 8.8M eeee ee eMeMeMe (8.8eeee) ee MMM (8.8eM) eee eeeee eeeeeeee eeee 8eee ee e eeeeeee eeee ee eee eeeee eeeee 88 (8.8eeee) ee MMM (8eM) ee 88°M eeeee eeeee. Mee eeeeeeeee eeee eee eeeeeee eee 88eee eee eeee ee eeee eeeeeeee (8.8eeee) eee eeeee. (Mee eeeeeeee ee 8 eeeee ee MeMM8MeMe eeee eee eeee eeeeeeee ee eeeeeeeee ee e eeeeeeee ee e eeeee ee eee eeeeeeee eeeeeeeeeee, eee eee ee eee eeeeeeeeeeee eeeeeee.[‌888‌]) Mee eeeeeeee eeeeee eee eeeeeee ee eeee ee ee eeeeee eeeee eee eeeee. M eeeeeeeee eeeeee eeeeeeee ee eeeeeeeeeeeeee (eeeeee eee) eee ee eee eeeeeeeeeeeee 8-eee eeeeee 88 ee eeeeeeeee eeee; eeeee: 8888%.

References


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