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Please login to access the full content or check if you have access via Variation 2: Ring Expansion by Nonradical Methods

DOI: 10.1055/sos-SD-026-01067

Chataigner, I.; Harrison-Marchand, A.; Maddaluno, J.Science of Synthesis, (2005261172.

In terms of anionic pathways, an aldolizationretro-aldolization sequence transforms 5- to 7-membered carbocyclic 3-oxo esters bearing a functionalized moiety at the α-position into 7- to 10-membered oxo esters 144.[‌93‌] Despite the relatively modest yields, this transformation remains of interest because it can expand the cycloalkanone ring by one or two carbon atoms, depending on the nature of the side chain and the solvent (Scheme 84).[‌436‌]

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