0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Variation 3: Arylation of Baylis–Hillman Adducts

DOI: 10.1055/sos-SD-026-01067

Chataigner, I.; Harrison-Marchand, A.; Maddaluno, J.Science of Synthesis, (2005261184.

The BaylisHillman adducts 178 undergo a palladium-catalyzed arylation to give the ­2-(arylmethyl)-3-oxoalkyl esters 179 (Scheme 107).[‌520‌] It is probable that the palladium β-elimination, which takes place after the CC bond is formed, transforms the allylic alcohol into an enol tautomer of the 3-oxo ester 179. This method is relatively general, and its yields are good to high.

Meeeee 888 Meeeeeeee ee MeeeeeMeeeeee Meeeeee[‌888‌]

Meeeeeeeeeee Meeeeeeee

8-(Meeeeeeeee)-8-eeeeeeee Meeeee 888; Meeeeee Meeeeeeee:[‌888‌]

M eeee ee eeeeee 8-eeeeeee-8-eeeeeeeeeeeeeeeeee 888 (8 eeee) eee ee eeee eeeeeee (8 eeee) ee MMM (8eM) eee eeeeeeee eee 888e ee eee eeeeeeee ee Me(MMe)8 (8.8ee, 8.88eeee), MeMMM8 (888ee, 8.8 eeee), eee MMMM (888ee, 8eeee). Mee eeeeeee eee eeee eeeeee, eeeeeee eeee M8M, eee eeeeeeeee eeee Me8M. Mee eeeeeee eeeee eee eeeee (Me8MM8) eee eee eeeeeee eee eeeeeeeeee. Mee eeeee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee, MeMMe/eeeeeee 8:88) eee eee eeeeeeeee eeeeeeee eeee eeeeeee eeeeeeee ee eeeeeeeeeee MMMM (Meee-eeee MMMM-MMM, MeMM).