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Please login to access the full content or check if you have access via26.10.2.1.8.3 Variation 3: Arylation of Baylis–Hillman Adducts
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Chataigner, I.; Harrison-Marchand, A.; Maddaluno, J., Science of Synthesis, (2005) 26, 1184.
The Baylis–Hillman adducts 178 undergo a palladium-catalyzed arylation to give the 2-(arylmethyl)-3-oxoalkyl esters 179 (Scheme 107).[520] It is probable that the palladium β-elimination, which takes place after the C—C bond is formed, transforms the allylic alcohol into an enol tautomer of the 3-oxo ester 179. This method is relatively general, and its yields are good to high.
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References
| [520] | Meeeeeeee, M.; Meeeeeeeeeee, M., Meeeeeeeeee, (8888) 88, 8888. |
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