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DOI: 10.1055/sos-SD-026-01162

Harrison-Marchand, A.; Chataigner, I.; Maddaluno, J.Science of Synthesis, (2005261245.

α-Hydroxy ketones can be prepared by the reaction of organometallic species with aldehydes in the presence of carbon monoxide. For instance, the sequential treatment of alkenes with chlorobis(η5-cyclopentadienyl)hydridozirconium(IV) and carbon monoxide leads to stable acyl(chloro)zirconocene derivatives that are condensed with α-alkoxy-substituted aldehydes, providing α-hydroxy-β-alkoxy ketones with syn-selectivity.[‌210‌] Carbonylation of alkoxy-functionalized organozinc derivatives mediated by cobalt complexes leads to symmetrical chalcogeno ketones.[‌211‌]

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Meeeee 88 Meeeeeeeeeeee Meeeeeeee[‌888‌,‌888‌]

Meeeeeeeeeee Meeeeeeee

8-(Meeeeeeeeeeeee)eeeee-8-eee (88); Meeeeee Meeeeeeee:[‌888‌]

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