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27.21.1.5 Method 5: Diazo Compounds by Elimination of Hydroxy Anions from Diazenolates (Diazotates)

DOI: 10.1055/sos-SD-027-00752

Heydt, H.Science of Synthesis, (200427862.

The generation of diazenolates[‌203‌] from suitable precursors is a good method for the synthesis of diazoalkanes especially diazomethane. In this respect, N-nitrosoamides, N-nitrosocarbamates, and N-nitrosoureas are of considerable interest for the synthesis of diazo compounds. In addition to their use as reagents in synthetic organic chemistry, they have been studied for their mutagenic and carcinogenic properties,[‌204‌] and suggested as antitumor agents.[‌205‌] Therefore, great care must be taken in handling these compounds.

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