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29.3.4.2.2 Method 2: Formation of α-Alkoxy Nitrogen Compounds

DOI: 10.1055/sos-SD-029-00127

Benneche, T.Science of Synthesis, (200729181.

Alkylation of 10H-quindoline (283) with iodomethyl methyl ether gives the 5-alkylated derivative 284 (Scheme 129);[‌327‌] no double alkylation occurs. Alkylation of quindoline under basic conditions gives the 10-alkylated isomer; quindoline cannot be alkylated under these conditions by bromomethyl methyl ether.[‌327‌]

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