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29.9 Product Class 9: Spiroketals

DOI: 10.1055/sos-SD-029-00536

Ley, S. V.; Milroy, L.-G.; Myers, R. M.Science of Synthesis, (200729613.

General Introduction

The spiroacetal, which is more commonly referred to as a spiroketal, is a distinguished architectural feature of many simple and complex natural products with important and varying biological properties. They exist in a number of differing ring arrangements and some of the most abundant include [6,6]-, [6,5]-, and [5,5]-spiroketals. There is also an array of dispiroketal combinations found in many natural products (Scheme 1).

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References