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DOI: 10.1055/sos-SD-029-00536

Ley, S. V.; Milroy, L.-G.; Myers, R. M.Science of Synthesis, (200729616.

Disconnecting the spiroketal motif at the two CO ketal bonds is by far the most common retrosynthetic step to the open-chain pre-spiroketal to be invoked. In the forward sense, dehydrative cyclization of the oxo diol is then a simple process in light of the thermodynamic preference for formation of the bicyclic OCO ketal bonding system.

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