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Please login to access the full content or check if you have access via29.9.1.1 Synthesis by Formation of Two C—O Bonds
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Ley, S. V.; Milroy, L.-G.; Myers, R. M., Science of Synthesis, (2007) 29, 616.
Disconnecting the spiroketal motif at the two C—O ketal bonds is by far the most common retrosynthetic step to the open-chain pre-spiroketal to be invoked. In the forward sense, dehydrative cyclization of the oxo diol is then a simple process in light of the thermodynamic preference for formation of the bicyclic O—C—O ketal bonding system.
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