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Please login or sign up for a free trial to access the full content. Variation 3: From Hydroxamic Acids and Imides

DOI: 10.1055/sos-SD-029-00649

Merino, P.Science of Synthesis, (200729711.

The reaction between the hydroxamate 26 and 2-(trimethylsilyl)ethoxymethyl chloride in the presence of Hünig's base and 4-(dimethylamino)pyridine in dichloromethane as solvent affords the 2-(trimethylsilyl)ethoxymethyl-protected ester 27 in 92% yield (Scheme 12).[‌13‌]

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