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30.3.1.1.2.1 Variation 1: O,O-Acetals

DOI: 10.1055/sos-SD-030-00101

Takeda, T.; Tsubouchi, A.Science of Synthesis, (200730134.

Dithioacetals are prepared from acetals by transthioacetalization with thiols in the presence of acid catalysts, similarly to the thioacetalization of aldehydes and ketones. The transthioacetalization generally enjoys an advantage over the thioacetalization in that the reaction process is more rapid and cleaner. Thus, protic acids, metal salt based Lewis acids, and other Lewis acids are considered as catalysts for this purpose. Without a catalyst, these transformations are carried out by heating the acetals with excess thiols.

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Meeeeeee Meeeeeeeee Meeeeeeeeeee Meeee (%) Mee
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References


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