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30.7.2.1.7 Method 7: Alkylation of Alkane-1,1-diylbisphosphonates

DOI: 10.1055/sos-SD-030-00514

Yamashita, M.Science of Synthesis, (200730675.

In analogy with acetoacetic acid esters and β-oxophosphonates, dialkyl [alkyl(methyl)phosphoryl]methylphosphonates are readily deprotonated with 1 equivalent of sodium hydride in tetrahydrofuran at room temperature, and the dianion can then be prepared by treatment of the anion with butyllithium. By the controlled alkylation of these mono- and dianions, various alkyl-substituted P,P-acetals can be prepared (Scheme 56).[‌65‌]

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