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Please login to access the full content or check if you have access via30.7.2.1.7 Method 7: Alkylation of Alkane-1,1-diylbisphosphonates
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Yamashita, M., Science of Synthesis, (2007) 30, 675.
In analogy with acetoacetic acid esters and β-oxophosphonates, dialkyl [alkyl(methyl)phosphoryl]methylphosphonates are readily deprotonated with 1 equivalent of sodium hydride in tetrahydrofuran at room temperature, and the dianion can then be prepared by treatment of the anion with butyllithium. By the controlled alkylation of these mono- and dianions, various alkyl-substituted P,P-acetals can be prepared (Scheme 56).[65]
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Meeeee 88 8-Meeeeeeeee ee Meeeeeeeee Meeeeeeeeeeeeeeeeeeeeee Meeee Meeeeeeee eeee-Meeeeeee[88]
Meeeee 88 8-Meeeeeeeeeee ee Meeeeeeeee Meeeeeeeeeeeeeeeeeeeeeee Meeee Meeeee Meeeeee/88-Meeee-8[88]
Meeeee 88 8-Meeeeeeeeee ee ee Meeeee-8,8-eeeeeeeeeeeeeeeeee[88]
Mee eeeeeeeeeee ee eeeeee-eeeeeeeeeee eeeeee-8,8-eeeeeeeeeeeeeeeeee eeeeee ee eeeeeeee ee eeeeeeeeeeeeeeeeeeeeeeee ee eeeeeeeeeeee ee eeeeeeee ee e eeeeee.[88] Mee eeeeeeeee eeeeee eeee-8-eeeeeeeeeeeee-8,8-eeeeeeeeeeeeeeeeeee eeeeeee eeeeeeeeeee ee eeee eeeeeeeeeee eeeeeeeeeeeeeee. Meeeeeeee ee eee eeeeeeeeeee eeeeeeeeeeeeeee ee eeeeeeeee eeeeeeeeeeeee ee eeeee e eeeeeee eeeeeee eeeee eee eeeeeeeeeeeee (eeeeeeeee)eeeeeeeeeeeeeee.[88]
References
[65] | Meeeeee, M. M. M.; Meeee, M. M.; MeMeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 888. |
[87] | Meeee, M. M.; Meeeee, M. M.; Meeeeee, M. M.; Meeeeee, M. M., Me.; Meeee, M. M.; Meeeeeeee, M. M.; Meeeeeeee, M.M., Meeee. Meeeee., (8888) 88, 888. |
[88] | Meeee, M.; Müeeeeeeee, M. M.; Meeeeee, M., Meee. Meeee. (Meeeeeee, Mee.), (8888) 888, 888. |
[89] | Meeeeeeeee, M. M.; Meeeee, M., M. Meeeeeeee. Meee., (8888) 888, 888. |
[90] | Meeee, M. M.; Meeeee, M. M., M. Meeeeeeee. Meee., (8888) 888, 8888. |
[91] | Meeeeeeeee, M. M. M. M.; eee eee Meee, M.; eee eee Meeee, M. M.; Meeee, M. M.; eee Meee, M. M., Meeeeeeeeee, (8888) 88, 8888. |
[92] | Meeeee, M. M.; Meeeee, M. M.; Meee, M. M.; Meeeeeee, M.; Meeeeee, M. M., MM 8 888 888, (8888); Meee. Meeee., (8888) 888, 888888. |
[93] | Meeeee, M. M.; Meeeee, M. M.; Meeeeee, M. M.; Meee, M. M., Meee. Mee. Meee.: Meeeeee., Meeeee. Meeee. Meeeee, (8888) 8, 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 88/8, 888.
- 8.Meeeee-Meee, (8888) M 88e, 8888.