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31.1.1.1.2.1 Variation 1: With 1-Fluoropyridinium Salts

DOI: 10.1055/sos-SD-031-00002

Sandford, G.Science of Synthesis, (20073131.

1-Fluoropyridinium salts, e.g. 7, prepared by passing fluorine through a solution of a pyridine in cold acetonitrile followed by the addition of either a Lewis acid or a suitable salt of a non-nucleophilic counteranion, such as tetrafluoroborate or trifluoromethanesulfonate, were originally introduced as site-selective electrophilic fluorinating agents (Scheme 11).[‌44‌] A wide range of pyridinium salts have been synthesized and some are commercially available. Related fluorinating reagents derived from 2,2-bipyridine are now marketed commercially.[‌45‌]

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