Science of Synthesis

Sandford, G., Science of Synthesis, (2007) 31, 57.

Mixtures of sodium nitrite and either aqueous or anhydrous hydrogen fluoride can be used for a one-pot transformation of aniline derivatives ‌50‌ into fluoroarene products ‌51‌ (‌Scheme 27‌).[‌136‌] Reactions performed using aqueous hydrogen fluoride are generally low yielding, with some exceptions, so anhydrous hydrogen fluoride is more commonly used as both the reagent and reaction medium. One-pot fluorodediazoniation by anhydrous hydrogen fluoride is used on a large scale for the industrial synthesis of fluorobenzene, fluorotoluenes,[‌137‌] and various other fluoroarenes.

‌Meeeee 88‌ Meeeeeeeeee ee Meeee Meeeee eeee Meeeeeee Meeee Meeeee Meeeeee/Meeeeeeee Meeeeeee Meeeeeee ee e Mee-Meee Meeeeee[‌888‌]

‌Meeeeeeeeee 88‌

MMMMMM: Meeeeee ee eee eeeeeeeeeeee eeeeeee eeeeeeee ee eeeee eeeeeeee eeeeeeee ee e eeeeeeee eeeeeeeeee eeeeeeeeeee, eeee eeeeeeeee ee eeeeee eeee eeee ee eeeee-eeeee eeeeeeeee ee eeeeeeeeeeee.

Meeeeeeeeeee Meeeeeeee

Meeeeeeeeeee ‌88‌; Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meeeeeee eeeeeeee eeeee eee eeeeeeee eeeeeeeeee eee eeeeeeeee eeeeeeeeeee ee eee eeeeeeeeeee eeeeee.

Meeee MM (88 eee) eee eeeee eeeeee ee ee eeeeeeeee ‌88‌ (8 eee) ee e 8-M, eee-eeeeee, Meeee eeeee eeeee eeeeee ee eee. Mee eeee eee eeeeeee ee 8°M eeeee eee MeMM8 (88.8 e, 8.8 eee) eee eeeee ee eeeee eeeeeeee eeee 8 e. Mee eeeee eee eeee eeeeeeeee ee ee eee-eeeeee Me eeeeee eeee eee eee eeeeeee eee eeeeee eeeee eeeeeeeeee eeeee eeeeeeeee ee M8 eee eeeeee. Mee eeeeeee eee eeee eeeeee, eeeeeee eeee eee, eee eeeee eeeeeeeee.

References

Meeeeee Meeeeeeeeee

• 8.Meeeee-Meee, (8888) 8/8, 888.
• 8.Meeeee-Meee, (8888) M 88e, 888.
• 8.Meeeee-Meee, (8888) M 88e, 888.