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31.1.1.5.2.2 Variation 2: Reaction with Hydrogen Fluoride/Pyridine Mixtures

DOI: 10.1055/sos-SD-031-00002

Sandford, G.Science of Synthesis, (20073158.

The low boiling point (19°C), high vapor pressure, and highly corrosive nature of anhydrous hydrogen fluoride makes use of this reagent unattractive for normal laboratory use. Consequently, much research has been devoted to the use of compounds that form extensive hydrogen-bonding networks with hydrogen fluoride, with the aim of decreasing the hazards of hydrogen fluoride without compromising its fluorinating ability. Solutions of hydrogen fluoride with strong inorganic acids, fluoride salts (e.g., potassium hydrogen difluoride or ammonium hydrogen difluoride), ethers,[‌138‌] or amines[‌139‌] can all be used as alternative reagents to hydrogen fluoride itself.

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8-M8MM8M8 888 88e [‌888‌]
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References


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