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31.6.1.1.9.1 Variation 1: Chromium Carbene Induced Benzannulation

DOI: 10.1055/sos-SD-031-00413

Thomas, A. W.Science of Synthesis, (200731523.

The reaction of the dihydropyranyl methoxy chromium carbene complexes 148 with hex-3-yn-2-one (149) provides, with a predictable regiochemical outcome, the phenolic diaryl ethers 150 as the major products through a Dötz benzannulation (Scheme 50).[‌207‌] The outcome of the reaction is generally independent of the solvent (acetonitrile, benzene, dichloromethane, or tetrahydrofuran).[‌208‌]

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