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31.6.1.1.12 Method 12: Synthesis from Benzo-1,4-quinones

DOI: 10.1055/sos-SD-031-00413

Thomas, A. W.Science of Synthesis, (200731531.

2-Bromobenzo-1,4-quinone (190)[‌224‌] reacts with phenols 191 to give phenoxybenzoquinones 192 in yields of 7981%: the products are important intermediates in the synthesis of diaryl ethers (Scheme 65). By the use of the appropriate phenol 193 (R1=Bn), combined with a reduction step using sodium dithionite, this efficient strategy provides access to the isodityrosine derivative K-13 (Scheme 65).[‌225‌]

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