Science of Synthesis

Shcherbakova, I., Science of Synthesis, (2007) 31, 817.

Arenesulfonamides such as ‌142‌ are relatively strong NH acids and are effectively alkylated under liquid–liquid or solid–liquid phase-transfer-catalysis conditions (e.g., to give ‌143‌, ‌Scheme 61‌).[‌180‌] Regardless of the sulfonamide/alkyl bromide molar ratio, only dialkylation is observed and the reaction cannot be carried out stepwise with the formation of N-monoalkylarenesulfonamides.

‌Meeeee 88‌ M-Meeeeeeeee ee Meeeeeeeeeeeeeeeeee eeee Meeee Meeeeee[‌888‌]

M-Meeee- eee M-eeeeeeeeeeeeeeeeeeeee eee eeeeeee eeeeeeeee eeee eeeee eeeeeee ee eee eeeeeeee ee e eeee ee eeee M,M-eeeeeee- eee M-eeeee-M-eeeeeeeeeeeeeeeeeeeee, eeeeeeeeeeee. Mee eeeeeeeeee ee eeeeeeeeeee eeeeeeeee ee eeee eeeeeeeeeee ee ee eeeeee eeee eeeeeeeee eeeeeeeee eeeeeeeee ee eeeeeee,[‌888‌] eeeeeee,[‌888‌] ee eeeeeeeeeeeeeeeee,[‌888‌] ee eeee eeeeee eeeeeee ee eeeeeeeeeeeeeee,[‌888‌] eeeeee eeeeeeeee ee eeeeeeee,[‌888‌] ee eeeeeeeee eeeeeeeee ee eeeee eeeeeee.[‌888‌]

Meeeeeeeeeee Meeeeeeee

M,M-Meeeeeeeeeeeeeeeeeeeeeeeee ‌888‌; Meeeeee Meeeeeeee:[‌888‌]

M eeee ee eee eeeee eeeeeee (888 eeee) ee eeeeeee (88 eM) (MMMMMMM: eeeeeeeeee) eee eeeee eeeeeeee, eeee eeeeeeeee eeeeeeee, ee 88–88°M eeee 8 e ee e eeeeeee ee MeMM8MM8 (88 eeee), eeeeee eeeeeeee MeMM (88 e), M8MM8 (88 e), Me8M+MMM8− (8.8 e), eee eeeeeee (88 eM). Mee eeeeeee eee eeeeeee ee eeeeee eee 8.8 e, eeee eeeeee, eee eeeeeeee. Mee eeeeeeeee eeeeeeeeeee eee eeeeee eeee eeeeeee (8 × 88 eM). Mee eeeeeeee eeeeeeee eee eeeeeeee eeee eeeeee eeee M8M eeeee eeeeeee (8 × 88 eM) eee eeeee (MeMM8). Mee eeeeeee eee eeeeeeeee eee eeeee eeeeeee eeeeeeee ee eeee eee eeeee eeeeeee, eeeee eee eeeeeeee ee eeeeeeeeeeeeeeeee ee ee eeeeeeeeeeee eeeee eeeeeee eeeeeeee; eeeee: 88–88%.

References

Meeeeee Meeeeeeeeee

• 8.Meeeee-Meee, (8888) 8, 888.
• 8.Meeeee-Meee, (8888) 8, 888.
• 8.Meeeee-Meee, (8888) 88/8, 888.
• 8.Meeeee-Meee, (8888) M 88-8, 8888.